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Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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The R-PLEX Human FAS Soluble Assay from Meso Scale Discovery is a multiplex immunoassay kit for quantifying fatty acid synthase (FAS) in human serum plasma and cell culture supernatants It uses MSD s electrochemiluminescence detection technology offering high sensitivity a 5-log dynamic range and low sample volume needs The kit includes a 96-well plate with capture antibodies for human FAS detection antibodies calibrators and necessary reagents Measuring FAS levels aids in understanding metabolic diseases and cancer metabolism with results in 3 5 hours
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The SPB Probe provides direct control and monitoring of actual sample temperature via a corrosion-resistant, PFA-coated temperature probe. Each probe is supplied with five Probe Watch Glasses and a probe holder.
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Methyltetrazine-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are compounds that contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Alkyl chain-based PROTAC linker
Used in the synthesis of PROTACs
Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
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Cy3 methyltetrazine (TZ-Cy3) is a click chemistry reagent that incorporates methyltetrazine building blocks, making it highly reactive with cyclooctene. It also functions as a tetrazine-modified fluorescent probe, suitable for analyzing protein phosphorylation in solution and within living cells.
Click chemistry reagent
Reactive with cyclooctene
Functions as a tetrazine-modified fluorescent probe
Analyzes protein phosphorylation in solution and within living cells
For research use only
Solid appearance, brown to reddish brown
Emission at 570 nm
Excitation at 550 nm
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An irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes; reduces the uptake of palmitate by mouse insulinoma MIN6 cells and RAW 264.7 macrophages
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SPDP-PEG4-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules that contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. These compounds exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the ubiquitin-proteasome system
Selectively degrades target proteins
For research use only
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
SPDP-PEG4-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It has a molecular weight of 559.65, a chemical formula of C23H33N3O9S2, and appears as a colorless to light yellow liquid.
PEG-based PROTAC linker
Used in PROTAC synthesis
Contains two different ligands connected by a linker
Targets an E3 ubiquitin ligase and a protein of interest
Utilizes the intracellular ubiquitin-proteasome system
Selectively degrades target proteins
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A secondary metabolite produced by some species of lichen that binds FAS-II enzymes to produce antibacterial and antiplasmodial effects; inhibits PfFabZ and PfFabI (IC50 = 10.7 and 36.1 µM, respectively) but shows low efficacy against the malaria parasite P. berghei (IC50 = 77.3 µM)
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