Crosslinking Reagents
Cayman Chemical Clobetasol PropIonate 10g
A corticosteroid; binds to glucocorticoid receptors in a cell-free assay (IC50 = 3.17 nM) and inhibits proliferation of primary human skin fibroblasts at 5 UG/ml; topical administration reduces croton oil-induced EAr edema in mice
Cayman Chemical LIthocholIc AcId 3sulfatS 50mg
A metabolite of lithocholic acid; water soluble and the primary form of lithocholic acid in the bile duct; forms a complex with calcium in vitro; biliary secretion increased in a rat model of streptozotocin-induced diabetes
Medchemexpress LLC Dbco-acid | 1353016-70-2 | MFCD28064336 | 99.7% | 305.33 g/mol | C19H15NO3 | 50 MG
DBCO-acid is a dibenzocyclooctyne-based click chemistry reagent used for strain-promoted alkyne-azide cycloaddition (SPAAC) and for synthesis of linker and bioconjugation reagents. It is provided in multiple pack sizes and is typically supplied with supporting analytical data and documentation.
- Used for strain-promoted alkyne-azide cycloaddition (SPAAC)
- Acid functional group enables conjugation via standard coupling chemistry
- High purity suitable for synthesis and bioconjugation applications
- Molecular weight approximately 305.33 g/mol
- CAS number 1353016-70-2 for unambiguous identification
Medchemexpress LLC Sulfo-SMCC (sodium) | 92921-24-9 | 99.86% | 5 MG
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker. It contains N-hydroxysuccinimide (NHS) ester and maleimide groups which react with primary amines and sulfhydryl groups, respectively.
- Hetero-bifunctional, noncleavable ADC crosslinker.
- Contains N-hydroxysuccinimide (NHS) ester and maleimide groups.
- Reacts with primary amines and sulfhydryl groups.
- Inhibits the end-to-end annealing of stabilized microtubules.
- Microtubules treated with Sulfo-SMCC show a constant mean length, independent of the incubation time.
Medchemexpress LLC Sulfo-SMCC (sodium) | 92921-24-9 | 99.9% | 100 MG
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker that bears N-hydroxysuccinimide (NHS) ester and maleimide groups, which react with primary amines and sulfhydryl groups, respectively. It inhibits the end-to-end annealing of stabilized Microtubules (MTs).
- Hetero-bifunctional, noncleavable ADC crosslinker.
- Contains N-hydroxysuccinimide (NHS) ester and maleimide groups for reaction with primary amines and sulfhydryl groups.
- Inhibits the end-to-end annealing of stabilized microtubules.
Cayman Chemical SulfosuccInImIdyl 32 BIot 25mg
An amine-reactive reagent; has been used as a derivatization reagent to identify PTMs in lysine-rich proteins and novel cell surface proteins of R. rickettsii
Medchemexpress LLC DBCO-sulfo-link-biotin | 1363444-70-5 | >95.0% | 653.77 g/mol | C31H35N5O7S2 | 5 MG
DBCO-sulfo-link-biotin is a cleavable linker reagent that combines a dibenzocyclooctyne (DBCO) reactive group with a sulfonated biotin tag for aqueous solubility and affinity capture. It is intended for click chemistry applications such as strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing biomolecules and for use in the synthesis of antibody-drug conjugates. For research use only.
- Enables SPAAC with azide-functionalized biomolecules.
- Contains a sulfonated biotin tag for aqueous solubility and affinity capture.
- Cleavable linker suitable for antibody-drug conjugate synthesis.
- Soluble in DMSO at high concentrations and formulatable for in vivo use.
- Powder stable at -20°C; solutions stable at -80°C for extended storage.
- Available in small milligram quantities for research workflows.
Cayman Chemical Sulfo-CynIn 5 5 10mg
An amine-reactive fluorescent probe; reacts with amine groups to form conjugates with peptides and proteins for detection by various fluorescent-based applications; has been used in cancer-targeted nanovesicles encapsulating perfluorooctyl bromide (PFOB) to identify their localization in mice; ex/em = 675/694 nm, respectively
Cayman Chemical Mc-Val-CIt-PABC-PNP 10mg
A peptide linker molecule; used in the synthesis of antibody-drug conjugates